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ROS-mediated cell signaling As outlined above, ROS have origin from two main sources: mitochondrial oxidative metabolism and processes of cellular response to xenobiotics, bacteria, and cytokines during which ROS are formed as a part of either signal transduction pathways or a cellular defense mechanism (Finkel 2011)

(5) Monthly fasting window is in synchrony with the moons rotation around the earth and lunar phases because the monthly fasting starts and ends when the new moon is sighted

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